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Article

The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.

The EMBO journal - 14 Nov 2007

Trewick Sarah C, Minc Elsa, Antonelli Richard, Urano Takeshi, Allshire Robin C

Abstract excerpt

Heterochromatin normally has prescribed chromosomal positions and must not encroach on adjacent regions. We demonstrate that the fission yeast protein Epe1 stabilises silent chromatin, preventing the oscillation of heterochromatin domains. Epe1 loss leads to two contrasting phenotypes: alleviation of silencing within heterochromatin and expansion of silent chromatin into neighbouring euchromatin. Thus, we propose...

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Identifiers

PMID: 17948055
DOI: 10.1038/sj.emboj.7601892
PMCID: PMC2048757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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