Article
The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.
EMBO reports - 1 Dec 2015
Sadeghi Laia, Prasad Punit, Ekwall Karl, Cohen Amikam, Svensson J Peter
Abstract excerpt
The maintenance of open and repressed chromatin states is crucial for the regulation of gene expression. To study the genes involved in maintaining chromatin states, we generated a random mutant library in Schizosaccharomyces pombe and monitored the silencing of reporter genes inserted into the euchromatic region adjacent to the heterochromatic mating type locus. We show that Leo1-Paf1 [a subcomplex of the RNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.