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Article

Enhanced polymerase activity confers replication competence of Borna disease virus in mice.

The Journal of general virology - 1 Nov 2007

Ackermann Andreas, Kugel Daniela, Schneider Urs, Staeheli Peter

Abstract excerpt

We previously showed that mouse adaptation of cDNA-derived Borna disease virus (BDV) strain He/80(FR) was associated exclusively with mutations in the viral polymerase complex. Interestingly, independent mouse adaptation of non-recombinant He/80 was correlated with different alterations in the polymerase and mutations in the viral glycoprotein. We used reverse genetics to demonstrate that changes in the...

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PMID: 17947539
DOI: 10.1099/vir.0.83170-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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