Article
Receptor-independent infection by mutant viruses newly isolated from the neuropathogenic mouse hepatitis virus srr7 detected through a combination of spinoculation and ultraviolet radiation.
Japanese journal of infectious diseases - 1 Jan 2011
Nomura Risa, Kashiwazaki Hiromi, Kakizaki Masatoshi, Matsuyama Shutoku, Taguchi Fumihiro, Watanabe Rihito
Abstract excerpt
The mouse hepatitis virus (MHV) has a high mutation rate, leading to various neuropathologies after infection. The srr7 mutant was isolated from the MHV strain cl-2, which induces characteristic spongiform degeneration in the brain. To investigate outcomes of srr7 infection, we re-cloned srr7(H2) from the viral stock srr7(Mix). During this re-cloning, we obtained the mutant viruses, Mu-1, Mu-2, and Br-1 which...
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