Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis.

Virology - 25 Apr 2007

Puig-Basagoiti Francesc, Tilgner Mark, Bennett Corey J, Zhou Yangsheng, Muñoz-Jordán Jorge L, García-Sastre Adolfo, Bernard Kristen A, Shi Pei-Yong

Abstract excerpt

An adaptive mutation (E249G) within West Nile virus (WNV) NS4B gene was consistently recovered from replicon RNAs in C3H/He mouse cells. The E249G is located at the C-terminal tail of NS4B predicted to be on the cytoplasmic side of the endoplasmic reticulum membrane. The E249G substitution reduce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Interferon-beta
Share to Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Viral

Share to Viral Nonstructural Proteins

Share to Virus Replication

Share to West Nile Fever

Share to West Nile virus

Source

Open in PubMed Open full text

Identifiers

PMID: 17178141
DOI: 10.1016/j.virol.2006.11.012
PMCID: PMC1952232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17178141-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis.PMID 17178141Read ↗

A Single Amino Acid Substitution in the West Nile Virus Nonstructural Protein NS2A Disables Its Ability To Inhibit Alpha/Beta Interferon Induction and Attenuates Virus Virulence in MiceSemantic proximity Read ↗

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4ASemantic proximity Read ↗

Murine norovirus mutants adapted to replicate in human cells reveal a post-entry restrictionSemantic proximity Read ↗

Mutations in West Nile virus nonstructural proteins that facilitate replicon persistence in vitro attenuate virus replication in vitro and in vivo.Semantic proximity Read ↗

A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in miceSemantic proximity Read ↗

Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling.Semantic proximity Read ↗

A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4Semantic proximity Read ↗

A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice.Semantic proximity Read ↗

Lethality of West Nile virus strains in a mouse modelSemantic proximity Read ↗

Molecular Determinants of Mouse Adaptation of Rat Hepacivirus.Semantic proximity Read ↗

Functional screening identifies candidate residues associated with nucleoprotein-mediated suppression of Borna disease virus 1 replicationSemantic proximity Read ↗

A single point mutation in the σ3 protein encoded by the reovirus S4 gene substantially attenuates the virulence of a highly myocarditic reassortant virus in neonatal miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.