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Article

Molecular Determinants of Mouse Adaptation of Rat Hepacivirus.

Journal of virology - 27 Apr 2023

Wolfisberg Raphael, Holmbeck Kenn, Billerbeck Eva, Thorselius Caroline E, Batista Mariana N, Fahnøe Ulrik, Lundsgaard Emma A, Kennedy Matthew J, Nielsen Louise, Rice Charles M, Bukh Jens, Scheel Troels K H

Abstract excerpt

The lack of robust immunocompetent animal models for hepatitis C virus (HCV) impedes vaccine development and studies of immune responses. Norway rat hepacivirus (NrHV) infection in rats shares HCV-defining characteristics, including hepatotropism, chronicity, immune responses, and aspects of liver pathology. To exploit genetic variants and research tools, we previously adapted NrHV to prolonged infection in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36971565
DOI: 10.1128/jvi.01812-22
PMCID: PMC10134885

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