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Article

Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2015

Wang Qingjie, Huo Leijun, He Jinlong, Ding Wenshuang, Su Hang, Tian Dongping, Welch Carrie, Hammock Bruce D, Ai Ding, Zhu Yi

Abstract excerpt

Epoxyeicosatrienoic acids (EETs) have beneficial effects on cardiovascular disease. Soluble epoxide hydrolase (sEH) metabolizes EETs to less active diols, thus diminishing their biological activity. sEH inhibitors can suppress the progression of atherosclerotic lesions in animal models. However, the regulation of sEH in vascular smooth muscle cells (VSMCs) and role of sEH in patients with atherosclerosis have not...

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Identifiers

PMID: 26453326
DOI: 10.1152/ajpheart.00289.2015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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