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Article

Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2006

Yang Xin, Murthy Vanishree, Schultz Kelly, Tatro Jeffrey B, Fitzgerald Katherine A, Beasley Debbie

Abstract excerpt

Inflammation plays a key role in atherogenesis, perhaps promoted by bacterial and viral products present within the artery wall. Vascular smooth muscle cells (VSMC) can express certain bacterially responsive Toll-like receptors (TLR), which promote a proinflammatory and proliferative VSMC phenotype when activated, but it is unknown whether virally activated TLR can regulate VSMC phenotype. Here we tested the role...

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Source

Identifiers

PMID: 16782847
DOI: 10.1152/ajpheart.00252.2006

Genes

TLR3
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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