Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction.

Journal of molecular and cellular cardiology - 1 May 2018

Kain Vasundhara, Ingle Kevin A, Kabarowski Janusz, Barnes Stephen, Limdi Nita A, Prabhu Sumanth D, Halade Ganesh V

Abstract excerpt

12/15 lipoxygenase (LOX) directs inflammation and lipid remodeling. However, the role of 12/15LOX in post-myocardial infarction (MI) left ventricular remodeling is unclear. To determine the role of 12/15LOX, 8-12 week-old C57BL/6 J wild-type (WT; n = 93) and 12/15LOX-/- (n = 97) mice were subjected to permanent coronary artery ligation and monitored at day (d)1 and d5 post-operatively. Post-MI d28 survival was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonate 12-Lipoxygenase
Share to Arachidonate 15-Lipoxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arachidonic Acid

Share to Cell Polarity

Share to Heart Failure

Share to Heme Oxygenase-1

Share to Myofibroblasts

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 29526491
DOI: 10.1016/j.yjmcc.2018.03.004
PMCID: PMC5940552

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction.PMID 29526491Read ↗

12/15-Lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammationSemantic proximity Read ↗

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.Semantic proximity Read ↗

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement miceSemantic proximity Read ↗

15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction.Semantic proximity Read ↗

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient miceSemantic proximity Read ↗

Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment.Semantic proximity Read ↗

Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic CardiomyopathySemantic proximity Read ↗

A Vascular Dissection and Rupture Linked Metabolite Acts Via BLT2 ReceptorSemantic proximity Read ↗

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.Semantic proximity Read ↗

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.Semantic proximity Read ↗

Resveratrol-Mediated Expression of KLF15 in the Ischemic Myocardium is Associated with an Improved Cardiac Phenotype.Semantic proximity Read ↗

Viral vector-mediated 12/15-lipoxygenase overexpression in vascular smooth muscle cells enhances inflammatory gene expression and migration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.