Article
Lysyl oxidase (LOX) in vascular remodelling. Insight from a new animal model.
Thrombosis and haemostasis - 1 Oct 2014
Orriols Mar, Guadall Anna, Galán María, Martí-Pàmies Ingrid, Varona Saray, Rodríguez-Calvo Ricardo, Briones Ana María, Navarro María A, de Diego Alicia, Osada Jesús, Martínez-González José, Rodríguez Cristina
Abstract excerpt
Lysyl oxidase (LOX) is an extracellular matrix-modifying enzyme that seems to play a critical role in vascular remodelling. However, the lack of viable LOX-deficient animal models has been an obstacle to deep in LOX biology. In this study we have developed a transgenic mouse model that over-expresses LOX in vascular smooth muscle cells (VSMC) to clarify whether LOX could regulate VSMC phenotype and vascular...
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