Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer.

Carcinogenesis - 1 Dec 2007

Mrkonjic Miralem, Raptis Stavroula, Green Roger C, Monga Neerav, Daftary Darshana, Dicks Elizabeth, Younghusband H Banfield, Parfrey Patrick S, Gallinger Steven S, McLaughlin John R, Knight Julia A, Bapat Bharati

Abstract excerpt

The most important indicator of colorectal cancer (CRC) risk is the presence of family history of the disease. Inherited genetic changes, such as single nucleotide polymorphisms, in key candidate genes may contribute to CRC risk. We investigated whether promoter polymorphisms in DNA mismatch repair (MMR) genes MSH2 and MSH6 are associated with the risk of CRC. We genotyped 929 CRC patients and 1098 control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to MutS Homolog 2 Protein

Share to MutS Homolog 3 Protein

Share to Newfoundland and Labrador

Share to Ontario

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 17942459
DOI: 10.1093/carcin/bgm229

Genes

MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer.PMID 17942459Read ↗

The 116G > A MSH6 and IVS1-1121C > T PMS2 Genes Polymorphisms Modulate the Risk of the Sporadic Colorectal Cancer Development in Polish Population.Semantic proximity Read ↗

Variations in mismatch repair genes and colorectal cancer risk and clinical outcome.Semantic proximity Read ↗

MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.Semantic proximity Read ↗

MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer.Semantic proximity Read ↗

MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer.Semantic proximity Read ↗

Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.Semantic proximity Read ↗

Molecular analysis of imperative polymorphisms of MLH1 gene in sporadic colorectal cancer.Semantic proximity Read ↗

Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors.Semantic proximity Read ↗

Intronic and promoter polymorphisms of hMLH1/hMSH2 and colorectal cancer risk in Heilongjiang Province of China.Semantic proximity Read ↗

Splice site mutations in mismatch repair genes and risk of cancer in the general population.Semantic proximity Read ↗

MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancer.Semantic proximity Read ↗

Variations in exon 7 of the MSH2 gene and susceptibility to gastrointestinal cancer in a Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.