Article
MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer.
Journal of the National Cancer Institute - 21 Mar 2007
Raptis Stavroula, Mrkonjic Miralem, Green Roger C, Pethe Vaijayanti V, Monga Neerav, Chan Yuen Man, Daftary Darshana, Dicks Elizabeth, Younghusband Banfield H, Parfrey Patrick S, Gallinger Steven S, McLaughlin John R, Knight Julia A, Bapat Bharati
Abstract excerpt
BACKGROUND: Although up to 30% of patients with colorectal cancer have a positive family history of colorectal neoplasia, few colorectal cancers can be explained by mutations in high-penetrance genes. We investigated whether polymorphisms in DNA mismatch repair genes are associated with the risk of colorectal cancer. METHODS: We genotyped 929 case patients and 1098 control subjects from Ontario and 430 case...
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