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Article

Evolution of imprinting via lineage-specific insertion of retroviral promoters

12 Dec 2019

Abstract excerpt

Imprinted genes are expressed from a single parental allele, with the other allele often silenced by DNA methylation (DNAme) established in the germline. While species-specific imprinted orthologues have been documented, the molecular mechanisms underlying the evolutionary switch from biallelic to imprinted expression are unknown. During mouse oogenesis, gametic differentially methylated regions (gDMRs) acquire...

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PMID: 31831741
DOI: 10.1038/s41467-019-13662-9

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