Article
Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.
Genome research - 1 Aug 2008
Monk David, Wagschal Alexandre, Arnaud Philippe, Müller Pari-Sima, Parker-Katiraee Layla, Bourc'his Déborah, Scherer Stephen W, Feil Robert, Stanier Philip, Moore Gudrun E
Abstract excerpt
Genomic imprinting is a developmentally important mechanism that involves both differential DNA methylation and allelic histone modifications. Through detailed comparative characterization, a large imprinted domain mapping to chromosome 7q21 in humans and proximal chromosome 6 in mice was redefined. This domain is organized around a maternally methylated CpG island comprising the promoters of the adjacent PEG10...
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