Article
Methylation at mouse Cdkn1c is acquired during postimplantation development and functions to maintain imprinted expression.
Genomics - 1 Dec 2004
Bhogal Balpreet, Arnaudo Anna, Dymkowski Alyson, Best Alison, Davis Tamara L
Abstract excerpt
Monoallelic expression of imprinted genes is generally associated with differential methylation. Methylation may be inherited as the gametic imprinting mark or may be acquired postfertilization. Here, we characterize a differentially methylated region associated with the mouse Cdkn1c gene and find that it is confined to a CpG island that begins 600 bp 5' of the promoter and extends into the transcription unit....
Topics
- Alleles
- Animals
- CpG Islands
- Cyclin-Dependent Kinase Inhibitor p57
- DNA Methylation
- Embryo Implantation
- Embryonic Development
- Female
- Gene Expression Regulation, Developmental
- Gene Silencing