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Article

Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.

Proceedings of the National Academy of Sciences of the United States of America - 16 Oct 2007

Grant Marianne A, Lazo Noel D, Lomakin Aleksey, Condron Margaret M, Arai Hiromi, Yamin Ghiam, Rigby Alan C, Teplow David B

Abstract excerpt

Amyloid beta-protein (Abeta) oligomers may be the proximate neurotoxins in Alzheimer's disease (AD). Recently, to elucidate the oligomerization pathway, we studied Abeta monomer folding and identified a decapeptide segment of Abeta, (21)Ala-(22)Glu-(23)Asp-(24)Val-(25)Gly-(26)Ser-(27)Asn-(28)Lys-(29)Gly-(30)Ala, within which turn formation appears to nucleate monomer folding. The turn is stabilized by hydrophobic...

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Identifiers

PMID: 17940047
DOI: 10.1073/pnas.0705197104
PMCID: PMC2034231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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