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Article

Polymorphism of Alzheimer's Abeta17-42 (p3) oligomers: the importance of the turn location and its conformation.

Biophysical journal - 19 Aug 2009

Miller Yifat, Ma Buyong, Nussinov Ruth

Abstract excerpt

Abeta(17-42) (so-called p3) amyloid is detected in vivo in the brains of individuals with Alzheimer's disease or Down's syndrome. We investigated the polymorphism of Abeta(17-42) oligomers based on experimental data from steady-state NMR measurements, electron microscopy, two-dimensional hydrogen exchange, and mutational studies, using all-atom molecular-dynamics simulation with explicit solvent. We assessed the...

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Identifiers

PMID: 19686665
DOI: 10.1016/j.bpj.2009.05.042
PMCID: PMC2726324

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