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Article

Protofibril assemblies of the arctic, Dutch, and Flemish mutants of the Alzheimer's Abeta1-40 peptide.

Biophysical journal - 15 Mar 2008

Fawzi Nicolas Lux, Kohlstedt Kevin L, Okabe Yuka, Head-Gordon Teresa

Abstract excerpt

Using a coarse-grained model of the Abeta peptide, we analyze the Arctic (E22G), Dutch (E22Q), and Flemish (A21G) familial Alzheimer's disease (FAD) mutants for any changes in the stability of amyloid assemblies with respect to the wild-type (WT) sequence. Based on a structural reference state of two protofilaments aligned to create the "agitated" protofibril as determined by solid-state NMR, we determine free...

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Open in PubMed Open full text

Identifiers

PMID: 18032553
DOI: 10.1529/biophysj.107.121467
PMCID: PMC2257882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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