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Article

Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein.

Journal of molecular biology - 1 Aug 2008

Krone Mary Griffin, Baumketner Andrij, Bernstein Summer L, Wyttenbach Thomas, Lazo Noel D, Teplow David B, Bowers Michael T, Shea Joan-Emma

Abstract excerpt

The effect of single amino acid substitutions associated with the Italian (E22K), Arctic (E22G), Dutch (E22Q) and Iowa (D23N) familial forms of Alzheimer's disease and cerebral amyloid angiopathy on the structure of the 21-30 fragment of the Alzheimer amyloid beta-protein (Abeta) is investigated by replica-exchange molecular dynamics simulations. The 21-30 segment has been shown in our earlier work to adopt a...

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Identifiers

PMID: 18597778
DOI: 10.1016/j.jmb.2008.05.069
PMCID: PMC2597412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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