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Article

Effects of the Arctic (E22-->G) mutation on amyloid beta-protein folding: discrete molecular dynamics study.

Journal of the American Chemical Society - 24 Dec 2008

Lam A R, Teplow D B, Stanley H E, Urbanc B

Abstract excerpt

The 40-42 residue amyloid beta-protein (Abeta) plays a central role in the pathogenesis of Alzheimer's disease (AD). Of the two main alloforms, Abeta40 and Abeta42, the longer Abeta42 is linked particularly strongly to AD. Despite the relatively small two amino acid length difference in primary structure, in vitro studies demonstrate that Abeta40 and Abeta42 oligomerize through distinct pathways. Recently, a...

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Source

Identifiers

PMID: 19053400
DOI: 10.1021/ja804984h

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DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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