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A turn for the worse: Aβ β-hairpins in Alzheimer’s disease

11 Apr 2024

Abstract excerpt

Amyloid-β (Aβ) oligomers are a cause of neurodegeneration in Alzheimer's disease (AD). These soluble aggregates of the Aβ peptide have proven difficult to study due to their inherent metastability and heterogeneity. Strategies to isolate and stabilize homogenous Aβ oligomer populations have emerged such as mutations, covalent cross-linking, and protein fusions. These strategies along with molecular dynamics...

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PMID: 38615460
DOI: 10.1016/j.bmc.2024.117715

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