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Article

Comparing the folding free-energy landscapes of Abeta42 variants with different aggregation properties.

Proteins - 1 Sept 2010

Mitternacht Simon, Staneva Iskra, Härd Torleif, Irbäck Anders

Abstract excerpt

The properties of the amyloid-beta peptide that lead to aggregation associated with Alzheimer's disease are not fully understood. This study aims at identifying conformational differences among four variants of full-length Abeta42 that are known to display very different aggregation properties. By extensive all-atom Monte Carlo simulations, we find that a variety of beta-sheet structures with distinct turns are...

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Identifiers

PMID: 20589631
DOI: 10.1002/prot.22775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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