Article
Aggregation Mechanism of Alzheimer's Amyloid β-Peptide Mediated by α-Strand/α-Sheet Structure.
International journal of molecular sciences - 7 Feb 2020
Balupuri Anand, Choi Kwang-Eun, Kang Nam Sook
Abstract excerpt
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and a widespread form of dementia. Aggregated forms of the amyloid β-peptide (Aβ) are identified as a toxic species responsible for neuronal damage in AD. Extensive research has been conducted to reveal the aggregation mechanism of Aβ. However, the structure of pathological aggregates and the mechanism of aggregation are not well...
Topics
- Amino Acid Motifs
- Amyloid beta-Peptides
- Humans
- Hydrogen Bonding
- Molecular Dynamics Simulation
- Mutation
- Protein Binding
- Protein Folding