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Article

Fitness landscape for nucleosome positioning.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jul 2013

Weghorn Donate, Lässig Michael

Abstract excerpt

Histone-DNA complexes, so-called nucleosomes, are the building blocks of DNA packaging in eukaryotic cells. The histone-binding affinity of a local DNA segment depends on its elastic properties and determines its accessibility within the nucleus, which plays an important role in the regulation of gene expression. Here, we derive a fitness landscape for intergenic DNA segments in yeast as a function of two...

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Identifiers

PMID: 23784778
DOI: 10.1073/pnas.1210887110
PMCID: PMC3704022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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