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Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2024

Kimura Tomoaki, Hirai Seiya, Kujirai Tomoya, Fujita Risa, Ogasawara Mitsuo, Ehara Haruhiko, Sekine Shun-Ichi, Takizawa Yoshimasa, Kurumizaka Hitoshi

Abstract excerpt

The Lys mutation of the canonical histone H3.1 Glu97 residue (H3E97K) is found in cancer cells. Previous biochemical analyses revealed that the nucleosome containing the H3E97K mutation is extremely unstable as compared to the wild-type nucleosome. However, the mechanism by which the H3E97K mutation causes nucleosome instability has not been clarified yet. In the present study, the cryo-electron microscopy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38972377
DOI: 10.1111/gtc.13143
PMCID: PMC11448003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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