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Article

Sin mutations alter inherent nucleosome mobility.

The EMBO journal - 28 Jan 2004

Flaus Andrew, Rencurel Chantal, Ferreira Helder, Wiechens Nicola, Owen-Hughes Tom

Abstract excerpt

Previous studies have identified sin mutations that alleviate the requirement for the yeast SWI/SNF chromatin remodelling complex, which include point changes in the yeast genes encoding core histones. Here we characterise the biochemical properties of nucleosomes bearing these mutations. We find that sin mutant nucleosomes have a high inherent thermal mobility. As the SWI/SNF complex can alter nucleosome...

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Identifiers

PMID: 14726954
DOI: 10.1038/sj.emboj.7600047
PMCID: PMC1271755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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