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Article

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

Cancer cell - 1 Oct 2007

Bruggeman Sophia W M, Hulsman Danielle, Tanger Ellen, Buckle Tessa, Blom Marleen, Zevenhoven John, van Tellingen Olaf, van Lohuizen Maarten

Abstract excerpt

The Polycomb group and oncogene Bmi1 is required for the proliferation of various differentiated cells and for the self-renewal of stem cells and leukemic cancer stem cells. Repression of the Ink4a/Arf locus is a well described mechanism through which Bmi1 can exert its proliferative effects. However, we now demonstrate in an orthotopic transplantation model for glioma, a type of cancer harboring cancer stem...

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Identifiers

PMID: 17936558
DOI: 10.1016/j.ccr.2007.08.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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