Article
The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression.
The Journal of biological chemistry - 14 Feb 2014
Liu Yongqing, Sánchez-Tilló Ester, Lu Xiaoqin, Huang Li, Clem Brian, Telang Sucheta, Jenson Alfred B, Cuatrecasas Miriam, Chesney Jason, Postigo Antonio, Dean Douglas C
Abstract excerpt
Ras mutations are frequent in cancer cells where they drive proliferation and resistance to apoptosis. However in primary cells, mutant Ras instead can cause oncogene-induced senescence, a tumor suppressor function linked to repression of the polycomb factor Bmi1, which normally regulates cell cycle inhibitory cyclin-dependent kinase inhibitors (cdki). It is unclear how Ras causes repression of Bmi1 in primary...
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