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Article

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.

Nature - 18 Mar 2004

Leung Carly, Lingbeek Merel, Shakhova Olga, Liu James, Tanger Ellen, Saremaslani Parvin, Van Lohuizen Maarten, Marino Silvia

Abstract excerpt

Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors. Conversely, loss of Bmi1 leads to haematological defects and severe progressive neurological abnormalities in which de-repres...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15029199
DOI: 10.1038/nature02385

Genes

BMI1
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15029199-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.PMID 15029199Read ↗

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