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Article

Targeting of BMI-1 with PTC-209 inhibits glioblastoma development

19 May 2018

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becomes an attractive therapeutic target. Here we showed that BMI-1 is highly expressed in GBM and especially enriched in glioblastoma stem cells (GSCs). Then we comprehensively...

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PMID: 29886801
DOI: 10.1080/15384101.2018.1469872

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