Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bmi1 and cell of origin determinants of brain tumor phenotype.

Cancer cell - 1 Oct 2007

Dirks Peter

Abstract excerpt

Glioblastomas frequently express oncogenic EGFR and loss of the Ink4a/Arf locus. Bmi1, a positive regulator of stem cell self renewal, may be critical to drive brain tumor growth. In this issue of Cancer Cell, Bruggeman and colleagues suggest that brain tumors with these molecular alterations can be initiated in both neural precursor and differentiated cell compartments in the absence of Bmi1; however,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Brain Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Glioblastoma

Share to Neoplasms, Experimental

Share to Polycomb Repressive Complex 1

Share to Stem Cells

Source

Identifiers

PMID: 17936553
DOI: 10.1016/j.ccr.2007.10.003

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bmi1 and cell of origin determinants of brain tumor phenotype.PMID 17936553Read ↗

Bmi1 marks intermediate precursors during differentiation of human brain tumor initiating cellsSemantic proximity Read ↗

Brain stem cells as the cell of origin in gliomaSemantic proximity Read ↗

Molecular pathogenesis of adult brain tumors and the role of stem cells.Semantic proximity Read ↗

The cellular origin for malignant glioma and prospects for clinical advancements.Semantic proximity Read ↗

Brain tumor stem cells: The cancer stem cell hypothesis writ largeSemantic proximity Read ↗

The developmental origin of brain tumours: a cellular and molecular frameworkSemantic proximity Read ↗

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes.Semantic proximity Read ↗

Stem cell origin of brain tumors.Semantic proximity Read ↗

The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity.Semantic proximity Read ↗

Developmental origins of brain tumors.Semantic proximity Read ↗

Cell of origin of glioma: biological and clinical implications.Semantic proximity Read ↗

Brain Metastasis-Initiating Cells: Survival of the FittestSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.