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Article

BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.

Oncogene - 27 Aug 2009

Hoenerhoff M J, Chu I, Barkan D, Liu Z-y, Datta S, Dimri G P, Green J E

Abstract excerpt

B-lymphoma Moloney murine leukaemia virus insertion region-1 (BMI1) is a member of the polycomb group of transcription repressors, which functions in stem cell maintenance and oncogenesis through the inhibition of the INK4A/ARF tumour suppressor locus. Overexpression of BMI1 is associated with poor prognosis in several human cancers, including breast cancer. We have previously shown that BMI1 collaborates with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19543317
DOI: 10.1038/onc.2009.165
PMCID: PMC2733922

Genes

BMI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.PMID 19543317Read ↗

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