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Article

Bmi1 Is Required for Hepatic Progenitor Cell Expansion and Liver Tumor Development

28 Sept 2012

Abstract excerpt

Bmi1 is a polycomb group transcriptional repressor and it has been implicated in regulating self-renewal and proliferation of many types of stem or progenitor cells. In addition, Bmi1 has been shown to function as an oncogene in multiple tumor types. In this study, we investigated the functional significance of Bmi1 in regulating hepatic oval cells, the major type of bipotential progenitor cells in adult liver,...

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PMID: 23029524
DOI: 10.1371/journal.pone.0046472

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