Article
Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia.
Cancer cell - 1 Oct 2007
Guasch Géraldine, Schober Markus, Pasolli H Amalia, Conn Emily Belmont, Polak Lisa, Fuchs Elaine
Abstract excerpt
Although TGFbeta is a potent inhibitor of proliferation, epithelia lacking the essential receptor (TbetaRII) for TGFbeta signaling display normal tissue homeostasis. By studying asymptomatic TbetaRII-deficient stratified epithelia, we show that tissue homeostasis is maintained by balancing hyperproliferation with elevated apoptosis. Moreover, rectal and genital epithelia, which are naturally proliferative,...
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