Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta.

The Journal of pathology - 1 Nov 2007

Baker K, Raut P, Jass J R

Abstract excerpt

Disruptions to the TGFbeta signalling pathway have been implicated in most human adenocarcinomas. As cancers progress, many acquire resistance to the growth-suppressing properties of TGFbeta while retaining sensitivity to its tumour-promoting effects. Microsatellite unstable colorectal cancers (MSI-H CRCs) possess truncating mutations in the type II TGFbeta receptor (TGFbetaRII) gene that have been assumed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autocrine Communication
Share to Benzamides
Share to Dioxoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microsatellite Instability

Share to Receptor, Transforming Growth Factor-beta Type I

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 17893910
DOI: 10.1002/path.2235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta.PMID 17893910Read ↗

Mutational inactivation of <i>TGFBR2</i> in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor β resistant cellsSemantic proximity Read ↗

Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.Semantic proximity Read ↗

Type III TGF-β Receptor Enhances Colon Cancer Cell Migration and Anchorage-Independent GrowthSemantic proximity Read ↗

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia.Semantic proximity Read ↗

Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.Semantic proximity Read ↗

Aggressive <i>KRAS</i> mutations direct TGF-β response towards partial EMT in patient-derived colorectal cancer tumoroidsSemantic proximity Read ↗

Development of TGF-beta resistance during malignant progression.Semantic proximity Read ↗

Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis.Semantic proximity Read ↗

Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas.Semantic proximity Read ↗

Tumor suppressor activity of the TGF-beta pathway in human cancers.Semantic proximity Read ↗

Microsatellite instability and gene mutations in transforming growth factor-beta type II receptor are absent in small bowel carcinoid tumors.Semantic proximity Read ↗

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.