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Article

Role of TGF-β receptor III localization in polarity and breast cancer progression

29 May 2014

Abstract excerpt

The majority of breast cancers originate from the highly polarized luminal epithelial cells lining the breast ducts. However, cell polarity is often lost during breast cancer progression. The type III transforming growth factor-β cell surface receptor (TβRIII) functions as a suppressor of breast cancer progression and also regulates the process of epithelial-to-mesenchymal transition (EMT), a consequence of which...

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PMID: 24870032
DOI: 10.1091/mbc.e14-03-0825

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