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Article

Escaping from the TGFbeta anti-proliferative control.

Carcinogenesis - 1 Nov 2006

Seoane Joan

Abstract excerpt

Transforming growth factor-beta (TGFbeta) has a crucial role in tissue homeostasis and disruption of the TGFbeta pathway has been implicated in many human diseases including cancer. As a potent inhibitor of epithelial cell proliferation, TGFbeta is a tumor suppressor. Tumor cells evade the antitumoral effect of TGFbeta, either by acquiring somatic mutations that blunt TGFbeta signaling or by selectively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16698802
DOI: 10.1093/carcin/bgl068

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