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Article

Keeping order in the neighborhood: new roles for TGFbeta in maintaining epithelial homeostasis.

Cancer cell - 1 Oct 2007

Wakefield Lalage M, Stuelten Christina

Abstract excerpt

TGFbetas are thought to have tumor suppressor activity in many organ systems, but receptor inactivation in mouse models has not previously resulted in increased spontaneous tumorigenesis. A study in this issue of Cancer Cell shows that mice with a targeted knockout of the type II TGFbeta receptor in stratified epithelia specifically develop spontaneous squamous cell carcinomas in the anogenital region, but not in...

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Identifiers

PMID: 17936552
DOI: 10.1016/j.ccr.2007.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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