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Article

TβRIII suppresses non-small cell lung cancer invasiveness and tumorigenicity

3 Jan 2008

Abstract excerpt

The transforming growth factor-beta (TGF-beta) superfamily has essential roles in lung development, regulating cell proliferation, branching morphogenesis, differentiation and apoptosis. Although most lung cancers become resistant to the tumor suppressor effects of TGF-beta, and loss or mutation of one of the components of the TGF-beta signaling pathway, including TbetaRII, Smad2 and Smad4 have been reported,...

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PMID: 18174241
DOI: 10.1093/carcin/bgm289

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