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Article

A novel TGF-β receptor II mutation (I227T/N236D) promotes aggressive phenotype of oral squamous cell carcinoma via enhanced EGFR signaling.

BMC cancer - 27 Nov 2020

Son Hwa-Kyung, Kim Dokyeong, Lim Yongwoon, Kim Jin, Park Iha

Abstract excerpt

BACKGROUND: Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but promotes tumor progression in later stages. We have previously identified various mutations of TGF-β receptor II (TβRII) in human oral squamous cell carcinoma (OSCC) samples. In the present study we...

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Identifiers

PMID: 33246423
DOI: 10.1186/s12885-020-07669-5
PMCID: PMC7694911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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