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Article

Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains.

Cellular immunology - 1 Jul 2007

Semiletova Natalya V, Shen Xiu-Da, Feldman Daniel M, Gao Feng, Mhoyan Ana, Liu Dhai, Busuttil Ronald W, Kupiec-Weglinski Jerzy W, Ghobrial Rafik M

Abstract excerpt

Functional topography of rat class I major histocompatibility complex (MHC) molecule was studied. The alpha1-helical sequences that are shared by class I RT1.A(l) and RT1.A(u) were substituted in the RT1.A(a) molecule to produce the composite [alpha(1h)(l/u)]-RT1.A(a) MHC class I allochimeric molecule. Dominant immunogenic epitopes that induce accelerated rejection were identified within the hypervariable regions...

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Source

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Identifiers

PMID: 17936255
DOI: 10.1016/j.cellimm.2007.04.008
PMCID: PMC3699404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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