Article
Mechanisms of indirect allorecognition: characterization of MHC class II allopeptide-specific T helper cell clones from animals undergoing acute allograft rejection.
Transplantation - 15 Apr 1998
Waaga A M, Chandraker A, Spadafora-Ferreira M, Iyengar A R, Khoury S J, Carpenter C B, Sayegh M H
Abstract excerpt
BACKGROUND: Recent evidence indicates that T cells primed via the indirect pathway of allorecognition play an important role in allograft rejection, although the effector mechanisms remain unknown. The purpose of this study was to characterize and study the in vivo function of self-restricted MHC allopeptide-specific T-cell clones generated from animals undergoing allograft rejection. METHODS AND RESULTS: We...
Topics
- Acute Disease
- Animals
- Clone Cells
- Graft Rejection
- Histocompatibility Antigens
- Histocompatibility Antigens Class II
- Immunodominant Epitopes
- Kidney Transplantation
- Lymphocyte Activation
- Male
- Phenotype
- Rats
- Rats, Inbred WF