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Article

Rat acute GvHD is Th1 driven and characterized by predominant donor CD4+ T-cell infiltration of skin and gut.

Experimental hematology - 1 Jun 2017

Boieri Margherita, Shah Pranali, Jalapothu Dasaradha, Zaitseva Olena, Walter Lutz, Rolstad Bent, Naper Christian, Dressel Ralf, Inngjerdingen Marit

Abstract excerpt

Acute graft-versus-host disease (aGvHD) remains a significant hurdle to successful treatment of many hematological disorders. The disease is caused by infiltration of alloactivated donor T cells primarily into the gastrointestinal tract and skin. Although cytotoxic T cells mediate direct cellular damage, T helper (Th) cells differentially secrete immunoregulatory cytokines. aGvHD is thought to be initiated...

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Source

Identifiers

PMID: 28238806
DOI: 10.1016/j.exphem.2017.02.002

Genes

CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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