Article
Prolongation of allogeneic heart graft survival in rats by administration of a peptide (a.a. 75-84) from the alpha 1 helix of the first domain of HLA-B7 01.
Transplantation - 15 Mar 1995
Cuturi M C, Josien R, Douillard P, Pannetier C, Cantarovich D, Smit H, Ménoret S, Pouletty P, Clayberger C, Soulillou J P
Abstract excerpt
Allospecific T lymphocytes mediate graft rejection through specific, direct or indirect, recognition of processed determinants of foreign MHC class I molecules. Small synthetic peptides derived from highly conserved sequences of the alpha 1 helix of the first domain of certain MHC class I molecules have been shown to inhibit CTL responses in vitro and to prolong graft survival in rats when combined with...
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