Prolongation of allogeneic heart graft survival in rats by administration of a peptide (a.a. 75-84) from the alpha 1 helix of the first domain of HLA-B7 01.

doi:10.1097/00007890-199503150-00003

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Article

Prolongation of allogeneic heart graft survival in rats by administration of a peptide (a.a. 75-84) from the alpha 1 helix of the first domain of HLA-B7 01.

Transplantation - 15 Mar 1995

Cuturi M C, Josien R, Douillard P, Pannetier C, Cantarovich D, Smit H, Ménoret S, Pouletty P, Clayberger C, Soulillou J P

Abstract excerpt

Allospecific T lymphocytes mediate graft rejection through specific, direct or indirect, recognition of processed determinants of foreign MHC class I molecules. Small synthetic peptides derived from highly conserved sequences of the alpha 1 helix of the first domain of certain MHC class I molecules have been shown to inhibit CTL responses in vitro and to prolong graft survival in rats when combined with...

Topics

Abdomen
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Cytokines
Graft Survival
Granzymes
HLA-B7 Antigen
Heart Transplantation
Interferon-gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-10

Interleukin-2

Lymphocyte Activation

Male

Membrane Glycoproteins

Molecular Sequence Data

Peptide Fragments

Source

Open in PubMed

Identifiers

PMID: 7886788
DOI: 10.1097/00007890-199503150-00003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7886788-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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