Article
T cell immunity to type II collagen in the biobreeding rat: the identification and characterization of RT1u-restricted T cell epitopes on alpha 1(II).
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2004
Cremer Michael A, Ye Xiu J, Myers Linda K, Brand David D, Rosloniec Edward F, Kang Andrew H
Abstract excerpt
Susceptibility to experimental collagen-induced arthritis in rodents is dependent on MHC class II elements to bind peptides from the type II collagen (CII) molecule. Although a substantial body of data has been reported in mice defining these peptide Ags, little has been reported in rats. In this study, we investigate the locations and sequences of CII peptides, which are bound by RT1(u) molecules, expressed by...
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