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Article

MHC class II isotype- and allele-specific attenuation of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2004

de Graaf Katrien L, Barth Silvia, Herrmann Martin M, Storch Maria K, Otto Christoph, Olsson Tomas, Melms Arthur, Jung Günther, Wiesmüller Karl-Heinz, Weissert Robert

Abstract excerpt

Most autoimmune diseases are associated with certain MHC class II haplotypes. Autoantigen-based specific immune therapy can lead either to beneficial or, in the context of inflammatory conditions, detrimental outcomes. Therefore, we designed a platform of peptides by combinatorial chemistry selected in a nonbiased Ag-independent approach for strong binding to the rat MHC class II isotype RT1.D(n) allelic product...

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Share to Autoantigens
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to Myelin-Associated Glycoprotein

Share to Myelin-Oligodendrocyte Glycoprotein

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Source

Identifiers

PMID: 15294998
DOI: 10.4049/jimmunol.173.4.2792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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