Article
MHC class II-regulated central nervous system autoaggression and T cell responses in peripheral lymphoid tissues are dissociated in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2001
Weissert R, de Graaf K L, Storch M K, Barth S, Linington C, Lassmann H, Olsson T
Abstract excerpt
We dissected the requirements for disease induction of myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in MHC (RT1 in rat) congenic rats with overlapping MOG peptides. Immunodominance with regard to peptide-specific T cell responses was purely MHC class II dependent, varied between different MHC haplotypes, and was linked to encephalitogenicity only in RT1.B(a)/D(a)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.