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Article

The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

BMC structural biology - 12 Oct 2007

Winnig Marcel, Bufe Bernd, Kratochwil Nicole A, Slack Jay P, Meyerhof Wolfgang

Abstract excerpt

BACKGROUND: Differences in sweet taste perception among species depend on structural variations of the sweet taste receptor. The commercially used isovanillyl sweetener neohesperidin dihydrochalcone activates the human but not the rat sweet receptor TAS1R2+TAS1R3. Analysis of interspecies combinations and chimeras of rat and human TAS1R2+TAS1R3 suggested that the heptahelical domain of human TAS1R3 is crucial for...

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Identifiers

PMID: 17935609
DOI: 10.1186/1472-6807-7-66
PMCID: PMC2099433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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