Article
Amiloride reduces the sweet taste intensity by inhibiting the human sweet taste receptor.
Biochemical and biophysical research communications - 25 Jun 2010
Imada Takamasa, Misaka Takumi, Fujiwara Satoshi, Okada Shinji, Fukuda Yusuke, Abe Keiko
Abstract excerpt
In mammals, sweet taste perception is mediated by the heterodimeric G-protein-coupled receptor, T1R2/T1R3. An interesting characteristic of this sweet taste receptor is that it has multiple ligand binding sites. Although there have been several studies on agonists of sweet taste receptors, little is known about antagonists of these receptors. In this study, we constructed a cell line stably expressing the human...
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