Article
Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor.
BMC neuroscience - 7 Apr 2005
Winnig Marcel, Bufe Bernd, Meyerhof Wolfgang
Abstract excerpt
BACKGROUND: The sweet taste inhibitor lactisole acts on the human sweet taste receptor heteromer TAS1R2-TAS1R3 but not on its rodent counterpart. Recently, it was shown that the lactisole sensitivity of the human sweet taste receptor involves the part of TAS1R3 encompassing the seven transmembrane regions but not the huge N-terminal domain. Using mutational analysis we investigated which amino acid residues...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.